People mainly take Choline for focus, mood, memory. Based on 159 first-hand reports and 280 meta-analyses & systematic reviews in the medical literature. Ranked #165 of 1,974 overall.
Of reports that state an outcome, 50% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.
PubMed 35365361 ↗Conclusion: The general quality of the studies, however, is poor with significant risk of bias in favor of the intervention. Other: PubMed and the Cochrane Library.
PubMed 36678257 ↗Conclusion: A large-scale analysis comprising ∼831 000 subjects revealed novel genetic determinants of MI and implicated SLC44A3 in the pathophysiology of vulnerable plaques.
PubMed 33532862 ↗Conclusion: Overall, most offspring would benefit from increased choline supply during the first 1000 days of life, particularly in relation to helping facilitate normal brain development. Health policies and guidelines should consider re-evaluation to help communicate and impart potential choline benefits through diet and/or supplementation approaches across this critical life stage.
PubMed 32531929 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“I take choline with it and I feel it for couple of hours..although mild.”
“Choline alone doesn't do anything for me.”
“ACL, choline and spiruline/chorella (dha)”
“more relevant evidence in its favor than piracetam and choline.”
“I'd prefer to not have my piracetam adulterated with choline as I feel choline is best taken with food”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate