PlainPill

Biotin

People mainly take Biotin for skin & hair. Based on 35 first-hand reports and 30 meta-analyses & systematic reviews in the medical literature. Ranked #503 of 1,974 overall.

26
User score
Mixed
17% positive6% mixed20% negative57% unclear

Of reports that state an outcome, 40% are positive.

Clinical research
AStrong research base
30
meta-analyses
77
RCTs
33,111
papers

What Biotin does, according to users

Of the people who reported each effect, the share who said it got better.

betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Clin Nutr · 2022 · Meta-analysis / systematic review
ESPEN micronutrient guideline

Conclusion: This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.

PubMed 35365361 ↗
Mult Scler Relat Disord · 2021 · Meta-analysis / systematic review
High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials

Conclusion: A moderate certainty of evidence suggests a potential benefit in favor of HDB administered for 12 to 15 months in terms of ITW25 in patients with PMS. However, an important trade-off of this benefit is the high certainty of evidence suggesting an increased incidence of laboratory test interference when HDB is taken.

PubMed 34332461 ↗
Cochrane Database Syst Rev · 2020 · Meta-analysis / systematic review
Dietary interventions for multiple sclerosis-related outcomes

Conclusion: There are a variety of controlled trials addressing the effects of dietary interventions for MS with substantial variation in active treatment, comparator, and outcomes of interest. PUFA administration may not differ when compared to alternatives with regards to relapse rate, disability worsening, or overall clinical status in people with MS, but evidence is uncertain. Similarly, at present, there is insufficient evidence to determine whether supplementation with antioxidants or other dietary interventions have any impact on MS-related outcomes.

PubMed 32428983 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

2500 mcgbefore bed
100 mcgas reported
400 mcgas reported
500ug-150mcgsplit into 4 doses
dailyas reported
5000 ugdaily

Reported side effects

How often each side effect came up across all reports.

acne ×7lab test ×1oily skin ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Biotin, collagen, zinc, selenium, niacin(b3). It may take 3 months until the effects are seen”
Source discussion ↗
“I have an vit a c e supp I take and collagen. I’ll add the biotin.”
Source discussion ↗
“Today I’m going to add Insolar Biotin CoQ10”
Source discussion ↗
“Biotin 100mcg”
Source discussion ↗
“I also take plenty of B5 and Biotin”
Source discussion ↗
Top discussions (5)

Other options for skin & hair

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate