PlainPill
MedicationEnergyLibido

Anastrozole

People mainly take Anastrozole for energy, libido. Based on 4 first-hand reports and 94 meta-analyses & systematic reviews in the medical literature. Ranked #1503 of 1,974 overall.

Compare with…Alternatives for energy
7
User score
Mixed
0% positive50% mixed25% negative25% unclear

Of reports that state an outcome, 0% are positive.

Clinical research
AStrong research base
94
meta-analyses
312
RCTs
2,317
papers

What Anastrozole does, according to users

Of the people who reported each effect, the share who said it got better.

Energy0% of 1Libido0% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Lancet Oncol · 2022 · Meta-analysis / systematic review
Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials

Conclusion: Using an aromatase inhibitor rather than tamoxifen in premenopausal women receiving ovarian suppression reduces the risk of breast cancer recurrence. Longer follow-up is needed to assess any impact on breast cancer mortality.

PubMed 35123662 ↗
Asian J Androl · 2020 · Meta-analysis / systematic review
A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility

Conclusion: Either steroidal (Testolactone) or nonsteroidal (Anastrozole and Letrozole) aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile. While the evidence is promising, future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications.

PubMed 31621654 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

0.5 mgtwice weekly

Reported side effects

How often each side effect came up across all reports.

headache ×1body aches ×1erectile dysfunction ×1fatigue ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“prescribed estrogen blocker”
Source discussion ↗
“I’ve been taking 0.5mg twice weekly (1mg/week total) for 2 weeks. I am completely crashed”
Source discussion ↗
“Try nation proactively provides anastrazole...archaic way of managing estradiol”
Source discussion ↗
“What's up with anastrozole abuse? Why are you using so much? That's not very biohacker nor will it help with longevity”
Source discussion ↗
Top discussions (4)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate