Conclusion: Using an aromatase inhibitor rather than tamoxifen in premenopausal women receiving ovarian suppression reduces the risk of breast cancer recurrence. Longer follow-up is needed to assess any impact on breast cancer mortality.
Anastrozole side effects
Across 52 first-hand reports, people mentioned a side effect 7 times (about 13 per 100 reports). The most common: headache, body aches, erectile dysfunction. User reports show what people notice — they can't tell you whether Anastrozole is safe for you.
Reported side effects
headache1
body aches1
erectile dysfunction1
fatigue1
low estrogen1
estro rebound1
gyno1
What got worse for some people
In their own words
“I’ve been taking 0.5mg twice weekly (1mg/week total) for 2 weeks. I am completely crashed”
“i could use something like a quarter Arimidex aswell, bc it has the same effect for me”
Is Anastrozole safe? What the research covers
AResearch: Strong94 meta-analyses · 312 randomized trials on PubMed
Lancet Oncol · 2022
Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trialsAsian J Androl · 2020
A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertilityConclusion: Either steroidal (Testolactone) or nonsteroidal (Anastrozole and Letrozole) aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile. While the evidence is promising, future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications.
Andrology · 2022
Efficacy and safety of letrozole or anastrozole in the treatment of male infertility with low testosterone-estradiol ratio: A meta-analysis and systematic review