MK-677 vs Tesamorelin for weight loss
Short answer: For weight loss, more users report improvement with Tesamorelin — 95% of 82 reports, versus 53% of 55 for MK-677.
MK-677 has 0 meta-analyses and 15 randomized trials on PubMed; Tesamorelin has 3 and 21.
Based on 978 reports about MK-677 and 265 about Tesamorelin. Not medical advice.
| MK-677 Substance | Tesamorelin Peptide | |
|---|---|---|
| Users say it helped | 39%helped479 reports · high confidence | 58%helped119 reports · high confidence |
| Verdict | Mixed | Mixed |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 0 / 15 | 3 / 21 |
| Mainly used for | ||
| Appetite % reporting improvement | 66% (228) | 100% (3) |
| Sleep % reporting improvement | 79% (170) | 70% (20) |
| Weight loss % reporting improvement | 53% (55) | 95% (82) |
| Recovery % reporting improvement | 99% (106) | 100% (10) |
| Performance % reporting improvement | 90% (87) | 88% (25) |
| Common side effects | water retention, fatigue, stomach issues, hunger | water retention, allergic reaction, anaphylaxis, swelling |
| Typical dose reported | 12.5 mg / before dinner | Not listed |
MK-677Full MK-677 profile →
What a user said
“From my own experience (also have suffered from poor sleep), i experienced a noticeable increase in sleep quality even with a low dose.”
TesamorelinFull Tesamorelin profile →
Latest review conclusion
However, limited data on long-term safety, optimal dosing strategies, and durability of treatment effects warrant caution. Future research should evaluate extended treatment duration, dose-response relationships, and patient-reported outcomes to establish comprehensive clinical utility.
J Int Assoc Provid AIDS Care, 2026 ↗What a user said
“I also added Tesamorelin 2 months in due to the harder time sleeping on Retatrutide and wanting to accelerate the burn of my visceral fats (2mg 5x a week). Worked like magic for me.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate