PlainPill

Rhodiola vs Saffron for mood

Short answer: For mood, more users report improvement with Saffron — 92% of 165 reports, versus 87% of 219 for Rhodiola.

Rhodiola has 18 meta-analyses and 45 randomized trials on PubMed; Saffron has 88 and 119.

Based on 1,376 reports about Rhodiola and 421 about Saffron. Not medical advice.

Rhodiola
Supplement
Saffron
Supplement
Users say it helped62%helped578 reports · high confidence62%helped223 reports · high confidence
Verdict
Mostly positive
Mostly positive
ResearchAResearch: StrongAResearch: Strong
Meta-analyses / RCTs18 / 4588 / 119
Mainly used for
Energy
% reporting improvement
90% (363)81% (21)
Mood
% reporting improvement
87% (219)92% (165)
Anxiety
% reporting improvement
78% (200)81% (84)
Focus
% reporting improvement
85% (102)79% (38)
Sleep
% reporting improvement
41% (17)72% (18)
Common side effectsjitteriness, insomnia, drowsiness, irritabilityheadache, appetite suppression, insomnia, vivid dreams
Typical dose reported200 mg / daily30 mg
Rhodiola
Latest review conclusion

The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection. In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes.

Nutrients, 2021 ↗
What a user said
“This one not only reduces my social anxiety but actually puts me in a good mood and makes me feel more social.”
Full Rhodiola profile →
Saffron
Latest review conclusion

Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested.

J Atten Disord, 2024 ↗
What a user said
“I just sneak some into whatever soup we are having. I honestly think it has made a huge difference.”
Full Saffron profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate