Nattokinase vs Vitamin K2 for heart & lipids
Short answer: For heart & lipids, more users report improvement with Nattokinase — 100% of 7 reports, versus 91% of 23 for Vitamin K2.
Nattokinase has 2 meta-analyses and 8 randomized trials on PubMed; Vitamin K2 has 36 and 99.
Based on 43 reports about Nattokinase and 697 about Vitamin K2. Not medical advice.
| Nattokinase Supplement | Vitamin K2 Supplement | |
|---|---|---|
| Users say it helped | 90%helped9 reports · few reports | 72%helped125 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 2 / 8 | 36 / 99 |
| Mainly used for | ||
| Heart & lipids % reporting improvement | 100% (7) | 91% (23) |
| Mood % reporting improvement | — | 93% (14) |
| Energy % reporting improvement | — | 100% (7) |
| Libido % reporting improvement | — | 80% (5) |
| Sleep % reporting improvement | — | 60% (5) |
| Common side effects | None reported | heart palpitations, anxiety, palpitations, insomnia |
| Typical dose reported | 200 mg / daily | 75 mcg |
This study further supports that nattokinase can be used as an effective adjunctive therapy for hypertension, but relatively low-dose supplementation of nattokinase may have no significant lipid-lowering effect. More work will need to be done to determine whether the positive efficacy of nattokinase on cardiovascular risk factors is dose-dependent.
Rev Cardiovasc Med, 2023 ↗“Nattokinase is known for reducing blood clotting and blood pressure. 'Doctors Best Natto-Serra' helped to lower my hemoglobin from 52 to 44.”
The results of this meta-analysis seem to indicate that VK2 supplementation has a positive effect on the maintenance and improvement of BMD LS in postmenopausal women, and it can also reduce the fracture incidence, serum uc-OC levels and the ratio of uc-OC to cOC. In conclusion, VK2 can indirectly promote bone mineralization and increase bone strength.
Front Public Health, 2022 ↗“i believe k2, B vitamins, and amino acids L carnitine and glutamine made a difference in my skin.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate