Nattokinase

Conclusion: This study further supports that nattokinase can be used as an effective adjunctive therapy for hypertension, but relatively low-dose supplementation of nattokinase may have no significant lipid-lowering effect. More work will need to be done to determine whether the positive efficacy of nattokinase on cardiovascular risk factors is dose-dependent.

Conclusion: Together, such efforts support the objectives of the COST Action PIMENTO (CA20128) in building a more robust evidence base on fermented foods and health. The protocol for this systematic review was registered with the Open Science Framework (OSF; registration ID: vg7f6; https://osf.io/vg7f6).