Kanna vs Ketamine for mood
Short answer: For mood, users rate them about the same: 94% report improvement with Kanna (84 reports) and 97% with Ketamine (62 reports).
Kanna has 8 meta-analyses and 0 randomized trials on PubMed; Ketamine has 854 and 1,957.
Based on 231 reports about Kanna and 141 about Ketamine. Not medical advice.
| Kanna Supplement | Ketamine Medication | |
|---|---|---|
| Users say it helped | 77%helped102 reports · high confidence | 65%helped65 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 8 / 0 | 854 / 1,957 |
| Mainly used for | ||
| Mood % reporting improvement | 94% (84) | 97% (62) |
| Anxiety % reporting improvement | 88% (42) | 90% (10) |
| Energy % reporting improvement | 92% (13) | 100% (3) |
| Focus % reporting improvement | 100% (6) | 100% (3) |
| Libido % reporting improvement | 100% (8) | — |
| Common side effects | drowsiness, appetite suppression, brain fog, agitation | dissociation, headache, fatigue, insomnia |
| Typical dose reported | 300mg sublingual | Not listed |
Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.
Nat Genet, 2024 ↗“Kanna tablets. Dissolve under the tongue...I can't sing Kannas praises enough. It's the instant cure for my brain fog, lack of energy, and lack of motivation.”
Compared with etomidate, ketamine probably results in more hemodynamic instability during the peri-intubation period and appears to have no effect on successful intubation on the first attempt or mortality. However, ketamine results in decreased need for the initiation of vasopressor use and decreases adrenal suppression compared with etomidate.
Crit Care Med, 2025 ↗“One thing that has really helped me tremendously, without the nasty side effects of SSRIs, is Ketamine infusions.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate