Ketamine vs Probiotics for mood
Short answer: For mood, users rate them about the same: 97% report improvement with Ketamine (62 reports) and 100% with Probiotics (54 reports).
Ketamine has 854 meta-analyses and 1,957 randomized trials on PubMed; Probiotics has 2,293 and 2,235.
Based on 141 reports about Ketamine and 479 about Probiotics. Not medical advice.
| Ketamine Medication | Probiotics Supplement | |
|---|---|---|
| Users say it helped | 65%helped65 reports · medium confidence | 63%helped144 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 854 / 1,957 | 2,293 / 2,235 |
| Mainly used for | ||
| Mood % reporting improvement | 97% (62) | 100% (54) |
| Digestion % reporting improvement | — | 84% (86) |
| Anxiety % reporting improvement | 90% (10) | 90% (29) |
| Focus % reporting improvement | 100% (3) | 70% (10) |
| Energy % reporting improvement | 100% (3) | 80% (10) |
| Common side effects | dissociation, headache, fatigue, insomnia | stomach issues, brain fog, diarrhea, withdrawal |
| Typical dose reported | Not listed | 2 capsules / daily |
Compared with etomidate, ketamine probably results in more hemodynamic instability during the peri-intubation period and appears to have no effect on successful intubation on the first attempt or mortality. However, ketamine results in decreased need for the initiation of vasopressor use and decreases adrenal suppression compared with etomidate.
Crit Care Med, 2025 ↗“One thing that has really helped me tremendously, without the nasty side effects of SSRIs, is Ketamine infusions.”
Some combinations of probiotics or strains may be beneficial in IBS. However, certainty in the evidence for efficacy by GRADE criteria was low to very low across almost all of our analyses.
Gastroenterology, 2023 ↗“What finally made a difference was taking probiotics...I felt better fairly quickly.”
Related comparisons
Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate