PlainPill

HGH vs Melanotan Ii for skin & hair

Short answer: For skin & hair, more users report improvement with HGH — 97% of 32 reports, versus 88% of 84 for Melanotan Ii.

HGH has 14 meta-analyses and 146 randomized trials on PubMed; Melanotan Ii has 1 and 1.

Based on 433 reports about HGH and 186 about Melanotan Ii. Not medical advice.

HGH
Peptide
Melanotan Ii
Peptide
Users say it helped65%helped199 reports · high confidence60%helped115 reports · high confidence
Verdict
Mostly positive
Mixed
ResearchAResearch: StrongBResearch: Moderate
Meta-analyses / RCTs14 / 1461 / 1
Mainly used for
Skin & hair
% reporting improvement
97% (32)88% (84)
Recovery
% reporting improvement
95% (80)—
Performance
% reporting improvement
81% (58)100% (5)
Weight loss
% reporting improvement
93% (44)100% (12)
Libido
% reporting improvement
100% (5)96% (48)
Common side effectswater retention, carpal tunnel, joint pain, stomach issuesnausea, flushing, freckles, moles
Typical dose reportedNot listedNot listed
HGH
Latest review conclusion

Many critical gaps remain in our knowledge of the pathogenesis, prevention, and management of endometrial trauma and IUAs. PROSPERO (ID: CRD42023366218).

Hum Reprod Update, 2025 ↗
What a user said
“one of my original accounts is regarding HGH . Posted it a while back . Helped me a lot.”
Full HGH profile →
Melanotan Ii
Latest review conclusion

Almost all studies are in the preclinical phase. There are currently no effective clinical treatments for MC4R-deficient obese patients, although MC4R agonists are being developed and are entering phase I and II trials.

Int J Obes (Lond), 2014 ↗
What a user said
“I've found that getting sun within 3-12 hours will produce the desired result.”
Full Melanotan Ii profile →

Related comparisons

Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate