Curcumin vs Melatonin for longevity
Short answer: For longevity, users rate them about the same: 100% report improvement with Curcumin (6 reports) and 100% with Melatonin (7 reports).
Curcumin has 538 meta-analyses and 553 randomized trials on PubMed; Melatonin has 688 and 1,128.
Based on 544 reports about Curcumin and 1,370 about Melatonin. Not medical advice.
| Curcumin Supplement | Melatonin Supplement | |
|---|---|---|
| Users say it helped | 61%helped180 reports · high confidence | 42%helped726 reports · high confidence |
| Verdict | Mostly positive | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 538 / 553 | 688 / 1,128 |
| Mainly used for | ||
| Sleep % reporting improvement | 80% (5) | 78% (915) |
| Pain & inflammation % reporting improvement | 91% (104) | 100% (7) |
| Mood % reporting improvement | 96% (45) | 32% (37) |
| Energy % reporting improvement | 83% (6) | 32% (25) |
| Anxiety % reporting improvement | 93% (15) | 44% (16) |
| Common side effects | vivid dreams, headache, nausea, dht suppression | drowsiness, vivid dreams, fatigue, depression |
| Typical dose reported | 1000 mg / daily | 0.5 mg / bedtime |
Curcumin and Curcuma longa Extract may improve symptoms and inflammation levels in people with arthritis. However, due to the low quality and small quantity of RCTs, the conclusions need to be interpreted carefully.
Front Immunol, 2022 ↗“I recently stopped taking Curcumin because of its affect on DHT and I was looking for an alternative measure to deal with inflammation as I feel it really helped with anxiety/depression.”
Overall, eszopiclone and lemborexant had a favorable profile, but eszopiclone might cause substantial adverse events and safety data on lemborexant were inconclusive. Doxepin, seltorexant, and zaleplon were well tolerated, but data on efficacy and other important outcomes were scarce and do not allow firm conclusions. Many licensed drugs (including benzodiazepines, daridorexant, suvorexant, and trazodone) can be effective in the acute treatment of insomnia but are associated with poor tolerability, or information about long-term effects is not available. Melatonin, ramelteon, and non-licensed
Lancet, 2022 ↗“I have taken it nightly for 19 years. Doses ranging from .1 to 10mg. Right now I take 3mg per night. It helps me sleep.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate