Bupropion vs Modafinil for mood
Short answer: For mood, more users report improvement with Bupropion — 70% of 172 reports, versus 64% of 125 for Modafinil.
Bupropion has 411 meta-analyses and 617 randomized trials on PubMed; Modafinil has 155 and 297.
Based on 444 reports about Bupropion and 1,613 about Modafinil. Not medical advice.
| Bupropion Medication | Modafinil Medication | |
|---|---|---|
| Users say it helped | 41%helped271 reports · high confidence | 50%helped936 reports · high confidence |
| Verdict | Mixed | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 411 / 617 | 155 / 297 |
| Mainly used for | ||
| Focus % reporting improvement | 71% (62) | 86% (689) |
| Energy % reporting improvement | 81% (57) | 93% (485) |
| Mood % reporting improvement | 70% (172) | 64% (125) |
| Anxiety % reporting improvement | 15% (34) | 30% (87) |
| Sleep % reporting improvement | 38% (8) | 21% (94) |
| Common side effects | anxiety, insomnia, irritability, tinnitus | insomnia, anxiety, headache, tolerance |
| Typical dose reported | Not listed | Not listed |
Our findings represent the most comprehensive available evidence base to inform patients, families, clinicians, guideline developers, and policymakers on the choice of ADHD medications across age groups. Taking into account both efficacy and safety, evidence from this meta-analysis supports methylphenidate in children and adolescents, and amphetamines in adults, as preferred first-choice medications for the short-term treatment of ADHD. New research should be funded urgently to assess long-term effects of these drugs.
Lancet Psychiatry, 2018 ↗“It really helped. I went from being suicidal to having hope and motivation within 3 days of starting the medication.”
Our findings represent the most comprehensive available evidence base to inform patients, families, clinicians, guideline developers, and policymakers on the choice of ADHD medications across age groups. Taking into account both efficacy and safety, evidence from this meta-analysis supports methylphenidate in children and adolescents, and amphetamines in adults, as preferred first-choice medications for the short-term treatment of ADHD. New research should be funded urgently to assess long-term effects of these drugs.
Lancet Psychiatry, 2018 ↗“It did make me focused and alert. I was working two jobs at the time and needed every ounce of energy I could muster.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate