Apigenin vs Magnesium Glycinate for sleep
Short answer: For sleep, users rate them about the same: 81% report improvement with Apigenin (77 reports) and 83% with Magnesium Glycinate (668 reports).
Apigenin has 36 meta-analyses and 11 randomized trials on PubMed; Magnesium Glycinate has 82 and 210.
Based on 277 reports about Apigenin and 1,693 about Magnesium Glycinate. Not medical advice.
| Apigenin Supplement | Magnesium Glycinate Supplement | |
|---|---|---|
| Users say it helped | 59%helped94 reports · medium confidence | 68%helped965 reports · high confidence |
| Verdict | Mixed | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 36 / 11 | 82 / 210 |
| Mainly used for | ||
| Sleep % reporting improvement | 81% (77) | 83% (668) |
| Anxiety % reporting improvement | 95% (41) | 81% (336) |
| Mood % reporting improvement | 80% (15) | 74% (103) |
| Energy % reporting improvement | 57% (7) | 66% (56) |
| Focus % reporting improvement | 100% (4) | 69% (54) |
| Common side effects | vivid dreams, drowsiness, irritability, liver injury | drowsiness, fatigue, vivid dreams, brain fog |
| Typical dose reported | 50 mg | 200 mg / occasionally |
The discovery of the beneficial effects of these natural active compounds in POL supports the idea that POL could be a promising novel candidate for the treatment and prevention of inflammation-related cancers of the digestive system. However, clinical data describing the mode of action of the naturally active compounds of POL are still lacking. In addition, pharmacokinetic data for POL compounds, such as changes in drug dose and absorption rates, cannot be extrapolated from animal models and need to be measured in patients in clinical trials. On the one hand, a systematic meta-analysis of the
J Ethnopharmacol, 2024 ↗“L theanine 200mg, apigenin 50mg, mag theo, mag biglycinate makes me pee too much, GABA 600mg, 3g taurine. I have anxiety and panic disorder late into nights. And this has cured about 80% for me.”
This review confirms that the quality of literature is substandard for physicians to make well-informed recommendations on usage of oral magnesium for older adults with insomnia. However, given that oral magnesium is very cheap and widely available, RCT evidence may support oral magnesium supplements (less than 1 g quantities given up to three times a day) for insomnia symptoms.
BMC Complement Med Ther, 2021 ↗“The brain fog started lifting. The constant low-grade anxiety that I had accepted as "normal" started to ease.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate