PlainPill

What people actually say

4,788 first-hand quotes, shortened but never edited — each links to the original discussion.

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SsrisMixed
“SSRIs were very effective at improving my executive function at first, but now they barely work, and Prozac is the only one that really works for me.”
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SsrisMixed
“I used Ssri s for a few months. it does work quite well for anxiety, but unfortunately the side effects turned me into an unmotivated zombie”
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“I really got better from anxiety ... on effexor. My personal miracle drug does not work for everyone.”
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“I tried Venlafaxine and my ADHD improved significantly. However, it also had a certain amount of excitotoxicity, and I couldn't sleep at night.”
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“I started Venlafaxine three months ago when I got depressed again...and it got me out of bed, but NAC was the game changer for me.”
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“I found that Venlafaxine was good once it down regulated my norephineprine. Before I was constantly full of somatic anxiety but now it’s definitely improved.”
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“When I quit Effexor many years ago, I had to slowly decrease the dose over a period that was twice as long as I had been on them. Brain zaps from hell.”
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“never actually found anything that helped. Not one thing... Supplements I've tried include fish oil pills, htp-5, fluoxetine, effexor, adderall, ritalin, vitamin b complexes, and st johns wort.”
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“I've been taking Effexor which has shown to be effective for some people. It has helped me some but it's not 100% gone.”
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“venlafaxine did something...This at least helps me sleep...it just gives me that flattened serotonin effect where everything is 'fine,' apathy, emotional blunting, low libido.”
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“after the second week I could only sleep 2 hours a night and I felt anxious and foggy all day.”
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“i had Effexor prescribed. It did not seem to help but was prone to crying fits on it and felt like crap.”
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“The withdrawal symptoms, including extreme anxiety, are absolutely hell and I recommend staying away from it.”
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“Be careful with Effexor. If you have to take it, and it really helped, go for it. I spent literally two years tapering off of it the withdrawals were that severe.”
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“effexor does fucking suck. It helped me at the time but after taking it for only a year I now have chronic fatigue”
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“I have been on effexor 150mg for 1 year now which helps almost cured the depression and helped me regain mental clarity”
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“I tried Venlafaxine and my ADHD improved significantly. However, it also had a certain amount of excitotoxicity, and I couldn't sleep at night”
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“i was on effexor which was marvelous until the libido side effects creeped in”
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SSRIMostly negative
“then i came to SSRI , it helped a little bit then.”
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SSRIMostly negative
“I only took them for those 25 days and quit because it made me feel 100% numb with zero emotions or pleasure.”
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SSRIMostly negative
“Started doing some therapy and an SSRI, and saw huge improvement in all my symptoms.”
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SSRIMostly negative
“I decided to try an SSRI one day and now my life has completely changed. Anxiety is gone, obsessive behavior/rituals are gone, agoraphobia is gone.”
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SSRIMostly negative
“My psychiatrist thought I was depressed, put me on SSRIs, but since serotonin counteracts with dopamine, it only made everything worse.”
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SSRIMostly negative
“I have done SSRI's and they didn't help. They made things slightly worse.”
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SSRIMostly negative
“I've taken an Ssri and it didn't help me with these things.”
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SSRIMostly negative
“Ive taken SSRI's & SNRI' and I either didnt feel much or they made me feel worse (especially venlafaxine, that shit made me wanna kms)”
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SSRIMostly negative
“I've been on SSRI for over a year : it doesn't improve my anhedonia (make it worse depending the med)”
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SSRIMostly negative
“This didn't work for me at all and had horrible side effects.”
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SSRIMostly negative
“they worked for me when I took a 3 month cycle and tapered off.”
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SSRIMostly negative
“I took for 3 months different SSRI's for anxiety and depression. I began having disgusting psychological side effects.”
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SSRIMostly negative
“SSRIs can have major side effects, but they can also save lifes, like my own...SSRIs on average don't really even beat placebo for MDD”
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SSRIMostly negative
“SSRIs prevent and reverse the worst of this... The only thing that worked was Klonopin... they really messed me up bad”
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SSRIMostly negative
“If I didn't take an ssri, I would have no energy and no motivation...sexual dysfunction”
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SSRIMostly negative
“during my time of SSRi's it did alleviate this heaviness albeit made things worse because of emotional blunting”
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IbuprofenMostly positive
“I've always had a positive response to ibuprofen and would take it morning and night if it wasn't for the side effects and agmatine provides the same anti-depressant effects of ibuprofen.”
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IbuprofenMostly positive
“I take 1600mgs of advil and a 100mgs of zinc supplements a night. Have noticed absolutely nothing. Except better sleep.”
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IbuprofenMostly positive
“I find curcumin works just as well, if not better, than ibuprofen.”
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IbuprofenMostly positive
“I tried paracetamol, ibuprofen, tramadol(all painkillers) and methyl salicylate to decrease inflammation prescribed by my doctor but nothing is working.”
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IbuprofenMostly positive
“I've noticed that NSAIDs (ibuprofen, naproxen, and especially meloxicam) not only cure migraine pain for me, but relieve everything else especially the terrible physiological effects.”
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IbuprofenMostly positive
“ibuprofen and weed is supposed to be a good way to inhibit memory loss but I didn't notice much of an effect when I tried.”
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