The short answer. There isn't much data on Xyrem yet — 7 mentions, 4 with a clear outcome — so treat these numbers as anecdotal. It is most often used for sleep: 80% of 5 reports say that improved. There is a moderate body of research — 2 meta-analyses and 13 trials.
From 7 mentions in total — the rest didn't say how it went and aren't counted.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Narcolepsy patients on SXB have significant reductions in cataplexy and daytime sleepiness. SXB is well tolerated in patients with narcolepsy, and most adverse events were mild to moderate in severity.
PubMed 22893778 ↗Conclusion: These results emphasize the need for awareness among clinicians and recreational users to minimize negative health consequences of recreational GHB use, particularly when high doses are used and GHB-induced comas occur.
PubMed 34151766 ↗How often each side effect came up across all reports.
First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.
“I was on Xyrem 10 years and zero issues. Zero tolerance. ... But this happened immediately after a crisis just stopped sleeping”
“derailed my usual amazing sleep using Xyrem (GHB) legally prescribed by doctor. Massive stress somehow made it go from absolutely beautiful deep sleep effectiveness to barely working”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate