PlainPill

Vitamin B5

People mainly take Vitamin B5 for sleep. Based on 9 first-hand reports and 3 meta-analyses & systematic reviews in the medical literature. Ranked #919 of 1,974 overall.

19
User score
Mostly positive
22% positive0% mixed0% negative78% unclear

Of reports that state an outcome, 100% are positive.

Clinical research
BModerate research base
3
meta-analyses
1
RCTs
319
papers

What Vitamin B5 does, according to users

Of the people who reported each effect, the share who said it got better.

betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

Front Immunol · 2024 · Meta-analysis / systematic review
Systematic review of innate immune responses against Mycobacterium tuberculosis complex infection in animal models

Conclusion: Simpler, physiologically relevant, and ethically sound models, such as G. mellonella, are needed for studying innate responses in MTBC infection. While insects lack adaptive immunity, they could provide insights into "pure" innate immune responses. The dissection of "pure," "sustained" (later than 7 days post-infection), and trained innate immunity presents additional challenges that require high-resolution temporospatial analytical methods. Identifying early innate immune mediators and targetable pathways in the blood and affected tissues could identify biomarkers for immunization efficiency,

PubMed 39949719 ↗
Food Res Int · 2026 · Meta-analysis / systematic review
Global evidence on vitamins in human milk: A 2002-2022 systematic review with a focus on China and implications for maternal diet and infant formula

Conclusion: These findings emphasize the need for nationally representative, lactation-stage-specific reference ranges for human milk vitamins in China. Such evidence is essential for optimizing maternal dietary strategies, for guiding rational vitamin fortification, and formulation of next-generation infant formulas that better reflect physiological nutrition.

PubMed 41956646 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

before bedas reported
right before sleepas reported
2-9 gdaily
100 mgas reported
500 mgdaily

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“when I do get sleep it's much higher quality, restful sleep”
Source discussion ↗
“take vitamin B5 before bed to help you produce the right substances to paralyze yourself during sleep”
Source discussion ↗
“then take vitamin B5 right before sleep. Both together (but especially the B5) help you to remain immobile while sleeping, which enables deep sleep”
Source discussion ↗
“Vitamin B5 (Pantothenic Acid) is required for the production of red blood cells, and for converting the nutrients in food into energy; but it is also essential for converting choline into acetylcholine.”
Source discussion ↗
“some extra vitamin B6 and B5”
Source discussion ↗
Top discussions (5)

Other options for sleep

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate