People mainly take Reishi for sleep, anxiety, mood. Based on 54 first-hand reports and 9 meta-analyses & systematic reviews in the medical literature. Ranked #252 of 1,974 overall.
Of reports that state an outcome, 79% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Nevertheless, the evidence is inconclusive to recommend the routine use of mushrooms for cancer patients. More trials are needed to explore mushroom use during and after cancer treatment.
PubMed 36995535 ↗Conclusion: Evidence from a small number of randomised controlled trials does not support the use of G lucidum for treatment of cardiovascular risk factors in people with type 2 diabetes mellitus. Future research into the efficacy of G lucidum should be placebo-controlled and adhere to clinical trial reporting standards.
PubMed 25686270 ↗Conclusion: Ex vivo studies conducted in human blood cells show the radioprotective effect of β-glucan of aqueous extract of G. lucidum, nevertheless, its implementation as radioprotector to humans is in need of further clinical research studies.
PubMed 32325828 ↗Conclusion: Therefore, this review summarizes the current knowledge on G. lucidum or its individual components in relation to chemotherapeutic efficacy, ability to reverse multidrug resistance, and chemotherapeutic toxicity.
PubMed 29256841 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Cordyceps and reishi have both helps my general feeling of well-being and my lungs”
“Medicinal mushrooms to calm your nervous system (eg. stress form no work, etc.) [Reishi ]”
“Reishi mushrooms.”
“Ganoderma lucidum aka Reishi might help as well.”
“adaptogens Rhodiola, Ashwagandha, Bacopa, Shilajit and Reishi four years ago, and I still find them amongst the most effective supplements for improving impulse-control and maintaining a level head.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate