PQQ
People mainly take PQQ for energy, performance, sleep. Based on 66 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #381 of 1,974 overall.
Of reports that state an outcome, 71% are positive.
What PQQ does, according to users
Of the people who reported each effect, the share who said it got better.
5 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“1. Haven't taken it yet, but plan on it.”
“Just ordered some CoQ10 w/ PQQ to try.”
“PQQ + CoQ10 for mitochondrial energy”
“a dose 5-fold higher than the recommended dose led to renal inflammation”
“PQQ”
Top discussions (5)
- How I reversed my epigenetic age by 10 years ↗
- Focusing on mitochondria health has been an absolute game changer ↗
- Rhonda Patrick's Supplement Stack ↗
- Megadose Melatonin accelerates sciatic nerve healing after spinal cord injury by significantly increasing NGF levels, in rats (2017) ↗
- Metabolic Agents That Enhance ATP Can Improve Cognitive Functioning: A Review of the Evidence for Glucose, Oxygen, Pyruvate, Creatine, and L-carnitine ↗
Other options for energy
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate