Front Pharmacol · 2024
The efficacy and safety of Chinese herbal medicine for mild cognitive impairment: a systematic review and meta-analysis of randomized placebo-controlled trialsPolygala side effects
Across 247 first-hand reports, people mentioned a side effect 8 times (about 3 per 100 reports). The most common: antisocial, changed heart, mania. User reports show what people notice — they can't tell you whether Polygala is safe for you.
Reported side effects
antisocial1
changed heart1
mania1
sleep cycle1
spaced out1
too strong1
malaise1
asthma exacerbation1
What got worse for some people
In their own words
“I’ve found Polygala was much better for focus whereas agmatine was way better for my mood.”
“I've tried everything dopamine wise, polygala, tyrosine, ginseng, schizandra, SAME-E. Alot of the times I would feel manic on these.”
“Polygala is great, but in my experience can be overstimulating and anxiety provoking.”
“I've tried huperzine and polygala and those days in which I took both I felt even dumber.”
“Polygala alone felt borderline useless to me. But in this combo it suddenly feels like the foundation that makes everything else work better.”
Is Polygala safe? What the research covers
BResearch: Moderate6 meta-analyses · 3 randomized trials on PubMed