PlainPill
Peptide

Orexin-A

Based on 4 first-hand reports and 8 meta-analyses & systematic reviews in the medical literature. Ranked #3134 of 4,149 overall.

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7
User score
Not enough data
0% positive0% mixed0% negative100% unclear

Of reports that state an outcome, 0% are positive.

Clinical research
AStrong research base
8
meta-analyses
19
RCTs
2,036
papers
High-risk compound. Peptides are not approved as supplements, carry serious and sometimes irreversible risks, are banned in competitive sport and may be restricted where you live. Nothing here is a recommendation to use it.

What Orexin-A does, according to users

Of the people who reported each effect, the share who said it got better.

No specific effects reported yet.
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Sleep Med · 2021 · Meta-analysis / systematic review
Cerebrospinal fluid orexin in Alzheimer's disease: a systematic review and meta-analysis

Conclusion: Results do not support broad differences in orexin in AD compared to controls, however, evolving diagnostic criteria may have affected findings across studies. Future research that examines orexin in AD over the longitudinal course of the disorder and explores potential links between phosphorylated tau and orexin are indicated.

PubMed 34364094 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

here and thereas reported

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.

No first-hand experiences with a clear outcome yet.
Top discussions (4)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate