MK-677 side effects
Across 978 first-hand reports, people mentioned a side effect 315 times (about 32 per 100 reports). The most common: water retention, fatigue, stomach issues. User reports show what people notice — they can't tell you whether MK-677 is safe for you.
Reported side effects
water retention109
fatigue64
stomach issues40
hunger38
anxiety29
high blood22
increased appetite10
increased hunger3
What got worse for some people
In their own words
“From my own experience (also have suffered from poor sleep), i experienced a noticeable increase in sleep quality even with a low dose.”
“MK-677 lately... The sleep that it gives me is extremely fragmented and the total sleep time is reduced. But during the day I feel like I've had a better than average nights sleep.”
“It worked! My nausea and sickness was quickly replaced with an extreme hunger.”
“MK677 had some conflicting effects for me. On one hand, hunger pangs all the time, water weight... On the other hand, sleep and recovery were incredible.”
“My own experience (so far) with 20mg/day is I have not had a massive increase in hunger...retained some fluids right away and gained a quick 4 lbs but that seems to be normalizing already (two weeks in).”
“Mk-677 gave me some serious water retention and fatigue, it doesn't happen to everyone though. Huge impact on the quality of my sleep, in a good way.”
Is MK-677 safe? What the research covers
BResearch: Moderate0 meta-analyses · 15 randomized trials on PubMed
None of the top reviews we found focus on safety. All research on MK-677.