Creatine vs Methylene Blue for focus
Short answer: For focus, more users report improvement with Methylene Blue — 100% of 23 reports, versus 93% of 249 for Creatine.
Creatine has 763 meta-analyses and 2,794 randomized trials on PubMed; Methylene Blue has 131 and 382.
Based on 2,279 reports about Creatine and 132 about Methylene Blue. Not medical advice.
| Creatine Supplement | Methylene Blue Substance | |
|---|---|---|
| Users say it helped | 72%helped1,048 reports · high confidence | 64%helped37 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 763 / 2,794 | 131 / 382 |
| Mainly used for | ||
| Performance % reporting improvement | 98% (542) | — |
| Energy % reporting improvement | 97% (268) | 95% (22) |
| Focus % reporting improvement | 93% (249) | 100% (23) |
| Mood % reporting improvement | 87% (125) | 100% (7) |
| Recovery % reporting improvement | 98% (95) | — |
| Common side effects | stomach issues, hair loss, insomnia, water retention | green urine, color change, agitation, serotonin syndrome |
| Typical dose reported | 5 g / daily | 0.5-5 mg / daily |
The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference = 0.48, 95% confidence interval 0.24-0.73, P = .001, I2 = 22%), and did not alter plasma urea values (standardized mean difference = 1.10, 95% confidence interval 0.34-1.85, P = .004, I2 = 28%). The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations.
J Ren Nutr, 2019 ↗“I actually feel a lot better. Mentally clearer and more balanced, like I have my brain back.”
Among critically ill adults with septic shock, based on low-certainty evidence, MB may reduce short-term mortality, duration of vasopressors, and hospital length of stay, with no evidence of increased adverse events. Rigorous randomized trials evaluating the efficacy of MB in septic shock are needed.
Crit Care Explor, 2024 ↗“Seems to be doing something. My Dual N back scores are up. My social anxiety also seems to be getting better. I am taking 60mcg 3x daily approximately every 5 hours.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate