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Methylated B Vitamins side effects

Across 38 first-hand reports, people mentioned a side effect 11 times (about 29 per 100 reports). The most common: anxiety, irritability, ocd symptoms. User reports show what people notice — they can't tell you whether Methylated B Vitamins is safe for you.

Reported side effects

anxiety7
irritability1
ocd symptoms1
jitteriness1
wrecked me1

What got worse for some people

Anxiety86% worse · 14% better · of 7

In their own words

“even the nootropics that some communities swear by did nothing for me (some that come to mind - racetams, tyrosine/NALT, NAC, methylated B vitamins...”
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“B-vitamins that are methylated gives me anxiety and if I take them long term I get superbad.”
Didn't helpRead the discussion ↗
“Methylated B vitamins messed with my brain - super anxiety. Made me almost hyper.”
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“If you have a COMT mutation, methylated b vitamins will give a ton of anxiety. I had this happen.”
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“I was taking a raw whole food multivitamin that contained methylated b vitamins... began to experience the absolute worst anxiety and OCD symptoms of my life”
MixedRead the discussion ↗
“I had also started taking certain vitamins (creatine, Sam-E, methylated B vitamins) in the recent past that was like throwing a match onto a gasoline canister.”
Didn't helpRead the discussion ↗

Is Methylated B Vitamins safe? What the research covers

BResearch: Moderate46 meta-analyses · 0 randomized trials on PubMed
Cochrane Database Syst Rev · 2024
Vitamin B12 supplementation during pregnancy for maternal and child health outcomes

Conclusion: Oral vitamin B12 supplementation during pregnancy may reduce the risk of maternal vitamin B12 deficiency and may improve maternal vitamin B12 concentrations during pregnancy or postpartum compared to placebo or no vitamin B12 supplementation, but the evidence is very uncertain. The effects of vitamin B12 supplementation on other primary outcomes assessed in this review were not reported, or were not reported in a format for inclusion in quantitative analyses. Vitamin B12 supplementation during pregnancy may improve maternal and infant vitamin B12 status, but the potential impact on longer-term

Methylated B Vitamins side effects: what 38 users report — PlainPill