Conclusion: SILA seems to be a relatively feasible and safe procedure without any superiority to CLA. Thus, SILA may not be a better approach for pediatric patients.
Cla side effects
Across 37 first-hand reports, people mentioned a side effect 6 times (about 16 per 100 reports). The most common: insulin resistance, heart stress, fatty acid. User reports show what people notice — they can't tell you whether Cla is safe for you.
Reported side effects
insulin resistance1
heart stress1
fatty acid1
side effects1
insomnia1
hormonal surge1
In their own words
“I wouldn't bother with CLA. Research has shown it either doesn't work or the results were inconclusive.”
“I used CLA for about 3 months beginning last November, but never noticed any results from it, heard the same from other users”
“I've tried supplementing CLA but the side effects are just too much”
“I went from about 200 lbs to about 175 over a 6-month period with basically no changes in diet using CLA (1250mg)”
“I took CLA for several months and it had precisely 0 effect”
Is Cla safe? What the research covers
AResearch: Strong103 meta-analyses · 196 randomized trials on PubMed
J Pediatr Surg · 2015
Systematic review and meta-analysis of single-incision versus conventional laparoscopic appendectomy in childrenBr J Surg · 2013
Systematic review and meta-analysis of single-incision versus conventional multiport appendicectomyConclusion: SILA is a safe procedure for the treatment of acute appendicitis, with comparable clinical outcome to CLA when undertaken by experienced laparoscopic surgeons.
JAMA · 2023
Efficacy and Tolerability of Gefapixant for Treatment of Refractory or Unexplained Chronic Cough: A Systematic Review and Dose-Response Meta-AnalysisConclusion: Compared with placebo, gefapixant (45 mg orally twice daily) led to modest improvements in cough frequency, cough severity, and cough-specific quality of life but increased taste-related adverse events.