Sulbutiamine vs Thiamine for energy
Short answer: For energy, more users report improvement with Thiamine — 100% of 14 reports, versus 94% of 86 for Sulbutiamine.
Sulbutiamine has 0 meta-analyses and 4 randomized trials on PubMed; Thiamine has 116 and 155.
Based on 489 reports about Sulbutiamine and 81 about Thiamine. Not medical advice.
| Sulbutiamine Supplement | Thiamine Supplement | |
|---|---|---|
| Users say it helped | 58%helped161 reports · high confidence | 88%helped20 reports · medium confidence |
| Verdict | Mixed | Mostly positive |
| Research | CResearch: Limited | AResearch: Strong |
| Meta-analyses / RCTs | 0 / 4 | 116 / 155 |
| Mainly used for | ||
| Energy % reporting improvement | 94% (86) | 100% (14) |
| Mood % reporting improvement | 76% (46) | 100% (4) |
| Focus % reporting improvement | 89% (46) | 100% (3) |
| Anxiety % reporting improvement | 85% (20) | 100% (4) |
| Memory % reporting improvement | 100% (12) | — |
| Common side effects | tolerance, headache, nausea, vomiting | paranoia, fatigue |
| Typical dose reported | 100mg / daily | 250-400 mg / daily |
“Combined with Sulbutamine was like a laser cruise control. I feel like a six year old kid in focus terms again.”
At present, it is unclear what the pathogenetic mechanisms for the development of neuropathy amongst those who chronically abuse alcohol are, and therefore, it is unknown whether it is attributed to the direct toxic effects of ethanol or another currently unidentified factor. There is presently sparse data to support a particular management strategy in alcohol-related peripheral neuropathy, but the limited data available appears to support the use of vitamin supplementation, particularly of B-vitamin regimens inclusive of thiamine.
J Neurol, 2019 ↗“I'll take a little extra (esp of b1) and physically feel calmer within the hour.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate