Progesterone vs Testosterone for sleep
Short answer: For sleep, more users report improvement with Progesterone — 100% of 12 reports, versus 79% of 19 for Testosterone.
Progesterone has 1,020 meta-analyses and 2,324 randomized trials on PubMed; Testosterone has 75 and 125.
Based on 30 reports about Progesterone and 924 about Testosterone. Not medical advice.
| Progesterone Medication | Testosterone Medication | |
|---|---|---|
| Users say it helped | 91%helped10 reports · few reports | 76%helped425 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 1,020 / 2,324 | 75 / 125 |
| Mainly used for | ||
| Performance % reporting improvement | — | 98% (180) |
| Mood % reporting improvement | — | 89% (117) |
| Hormones % reporting improvement | 100% (2) | 91% (101) |
| Energy % reporting improvement | — | 93% (88) |
| Libido % reporting improvement | — | 90% (78) |
| Common side effects | intolerance, hormone changes, next day | suppression, hair loss, acne, water retention |
| Typical dose reported | Not listed | Not listed |
MHT improves flow-mediated arterial dilation (FMD) but fails to lower the risk of all-cause death and cardiovascular events, and increases the risk of stroke and venous thrombosis in postmenopausal women. Early acceptance of MHT not only reduces the risk of all-cause death and cardiovascular events but also further improves FMD, although the risk of stroke and venous thrombosis is not reduced. There is no difference in the outcome of cardiovascular system endpoints between mono-estrogen therapy and combination therapy of estrogen and progesterone.
BMC Womens Health, 2024 ↗“I used to struggle with this as a perimenopause symptom. Progesterone has helped a lot.”
The guidelines also provide recommendations regarding identification of patients, dosing, monitoring, and follow-up. This Practice Pearl will discuss evidence-based testosterone therapy for management of HSDD in postmenopausal women.
Menopause, 2023 ↗“Feel the best I've ever felt in my life. TRT and peptides have been game changers for me!”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate