PlainPill

Methyl B12 vs Methyl Folate for mood

Short answer: For mood, users rate them about the same: 100% report improvement with Methyl B12 (6 reports) and 100% with Methyl Folate (4 reports).

Methyl B12 has 2 meta-analyses and 2 randomized trials on PubMed; Methyl Folate has 1 and 1.

Based on 42 reports about Methyl B12 and 21 about Methyl Folate. Not medical advice.

Methyl B12
Supplement
Methyl Folate
Supplement
User score5347
Verdict
Mostly positive
Mostly positive
Positive
of reports that state an outcome
78%72%
Reports4221
ResearchBResearch: ModerateBResearch: Moderate
Meta-analyses / RCTs2 / 21 / 1
Mainly used for
Focus
% reporting improvement
—67% (3)
Energy
% reporting improvement
89% (9)50% (2)
Anxiety
% reporting improvement
100% (2)50% (2)
Mood
% reporting improvement
100% (6)100% (4)
Common side effectsanxiety, whacky effects, feeling likejitteriness
Typical dose reportedhigh dose lozenge / once or twice a week at night2 lozenges daily
Methyl B12
Latest review conclusion

Current evidence for the use of supplements for correcting nutritional deficiencies in children with ASD and to improve the symptoms is little. More studies are needed.

Eur J Nutr, 2018 ↗
What a user said
“I took a sub-lingual Jarrow 5000 Methyl B-12 supplement, and felt more energetic and felt a dull sensation on my forhead.”
Full Methyl B12 profile →
Methyl Folate
Latest review conclusion

The areas of neurology and psychiatry have shown great advances regarding the deepening of knowledge in prophylaxis and pathophysiology, as well as in the treatment of established diseases. The recognition of the role of nutrition as an adjunct to these processes is currently growing. The search in scientific bases for neuro nutrients reveals a great growth of publications related to this theme. In the present text, some of these nutrients were explored to verify the current state of knowledge.

Cent Nerv Syst Agents Med Chem, 2023 ↗
What a user said
“I was able to address my social anxiety and depression by figuring out my body doesn't produce it's on methyl folate, so a change in my diet was life changing.”
Full Methyl Folate profile →

Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate