People mainly take Methyl B12 for mood, energy, anxiety. Based on 16 first-hand reports and 2 meta-analyses & systematic reviews in the medical literature. Ranked #122 of 1,974 overall.
Of reports that state an outcome, 81% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Current evidence for the use of supplements for correcting nutritional deficiencies in children with ASD and to improve the symptoms is little. More studies are needed.
PubMed 28884333 ↗Conclusion: The use of dietary supplements in children with autism seems to be a safe practice with encouraging data about their clinical efficacy. More studies are needed to further investigate this issue.
PubMed 28438367 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“NAC, Methyl-b12 and Curcumin”
“take methylfolate, methyl-b12 and P5P which are absolute game changers”
“I haven't noticed a positive or negative change when taking them.”
“Anxiety and mental clutter feel toned down, and I feel like I have some control over my mood swings now.”
“Nice methylfolate and methyl b12 fixed my life a bit too.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate