LSD vs LSD Microdose for mood
Short answer: For mood, more users report improvement with LSD Microdose — 100% of 12 reports, versus 91% of 32 for LSD.
LSD has 122 meta-analyses and 202 randomized trials on PubMed; LSD Microdose has 12 and 0.
Based on 134 reports about LSD and 31 about LSD Microdose. Not medical advice.
| LSD Substance | LSD Microdose Substance | |
|---|---|---|
| Users say it helped | 60%helped56 reports · medium confidence | 83%helped18 reports · few reports |
| Verdict | Mixed | Mostly positive |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 122 / 202 | 12 / 0 |
| Mainly used for | ||
| Mood % reporting improvement | 91% (32) | 100% (12) |
| Focus % reporting improvement | 91% (22) | 67% (12) |
| Anxiety % reporting improvement | 65% (17) | 100% (2) |
| Energy % reporting improvement | 100% (8) | 100% (4) |
| Common side effects | hppd, psychosis, anxiety, visual snow | tolerance buildup |
| Typical dose reported | 10-20 mcg / daily | 10-20 µg |
Nearly a third of the articles reported that no participants reported lasting adverse effects. Our analyses suggest that psychedelics reduce negative mood, and have potential efficacy in other mental disorders, such as substance-use disorders and PTSD.
Psychiatry Res, 2024 ↗“The only thing that works for me is low dose LSD or MDMA (but not MDA)”
Prim Care Companion CNS Disord 2024;26(1):23r03581. Author affiliations are listed at the end of this article.
Prim Care Companion CNS Disord, 2024 ↗“LSD-Microdose: Seems to provoke healthy decisions in me. Helps overcoming conditioned behavior. Gives me some amount of energy and better concentration.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate