L-Citrulline vs Omega-3 for heart & lipids
Short answer: For heart & lipids, more users report improvement with L-Citrulline — 94% of 16 reports, versus 76% of 58 for Omega-3.
L-Citrulline has 14 meta-analyses and 101 randomized trials on PubMed; Omega-3 has 1,341 and 3,093.
Based on 181 reports about L-Citrulline and 1,959 about Omega-3. Not medical advice.
| L-Citrulline Supplement | Omega-3 Supplement | |
|---|---|---|
| User score | 57 | 47 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 76% | 66% |
| Reports | 181 | 1,959 |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 14 / 101 | 1,341 / 3,093 |
| Mainly used for | ||
| Weight loss % reporting improvement | — | 100% (2) |
| Focus % reporting improvement | 67% (3) | 82% (129) |
| Energy % reporting improvement | 100% (7) | 74% (42) |
| Sleep % reporting improvement | — | 79% (24) |
| Anxiety % reporting improvement | 100% (2) | 75% (69) |
| Mood % reporting improvement | 100% (2) | 82% (201) |
| Memory % reporting improvement | — | 78% (50) |
| Performance % reporting improvement | 97% (30) | 88% (16) |
| Recovery % reporting improvement | 100% (3) | 90% (20) |
| Pain & inflammation % reporting improvement | 100% (2) | 91% (82) |
| Digestion % reporting improvement | — | 22% (9) |
| Libido % reporting improvement | 97% (37) | 71% (14) |
| Hormones % reporting improvement | 50% (2) | 100% (2) |
| Blood sugar % reporting improvement | — | 50% (2) |
| Heart & lipids % reporting improvement | 94% (16) | 76% (58) |
| Skin & hair % reporting improvement | — | 89% (38) |
| Immunity % reporting improvement | — | 60% (10) |
| Longevity % reporting improvement | — | 86% (7) |
| Common side effects | dizziness, headache, eye bags, tooth damage | brain fog, anxiety, depression, fatigue |
| Typical dose reported | 8 g / 3x/week | sparingly |
Foods rich in polyphenols and nitrate provide trivial benefits for endurance exercise performance, although these effects may be food dependent. Highly trained endurance athletes do not appear to benefit from consuming nitrate-rich foods but may benefit from polyphenol consumption. Further research into food sources, dosage and supplementation duration to optimise the ergogenic response to polyphenol consumption is warranted. Further studies should evaluate whether differential sex-based responses to nitrate and polyphenol consumption are attributable to physiological differences or sample siz
J Int Soc Sports Nutr, 2021 ↗“Something I found that makes my meds work way better is Citrulline 2g + Arginine 2g twice daily.”
For glycated hemoglobin, there was no significant effect in the meta-analysis. This systematic review with meta-analysis demonstrated that supplementation with omega-3 has protective effects on diabetes parameters.
Crit Rev Food Sci Nutr, 2022 ↗“I do supplement a lot of fish oil and vitamin A as retinyl palmitate though. It has really helped my depression, anxiety and ADHD and has enabled me to stop using more serious psychiatric drugs for those things.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate