Curcumin vs Tianeptine for mood
Short answer: For mood, users rate them about the same: 96% report improvement with Curcumin (45 reports) and 95% with Tianeptine (148 reports).
Curcumin has 538 meta-analyses and 553 randomized trials on PubMed; Tianeptine has 18 and 42.
Based on 544 reports about Curcumin and 322 about Tianeptine. Not medical advice.
| Curcumin Supplement | Tianeptine Medication | |
|---|---|---|
| Users say it helped | 61%helped180 reports · high confidence | 63%helped155 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 538 / 553 | 18 / 42 |
| Mainly used for | ||
| Mood % reporting improvement | 96% (45) | 95% (148) |
| Pain & inflammation % reporting improvement | 91% (104) | 67% (3) |
| Anxiety % reporting improvement | 93% (15) | 95% (62) |
| Focus % reporting improvement | 78% (9) | 93% (14) |
| Energy % reporting improvement | 83% (6) | 86% (14) |
| Common side effects | vivid dreams, headache, nausea, dht suppression | addiction, withdrawal, tolerance, headache |
| Typical dose reported | 1000 mg / daily | Not listed |
Curcumin and Curcuma longa Extract may improve symptoms and inflammation levels in people with arthritis. However, due to the low quality and small quantity of RCTs, the conclusions need to be interpreted carefully.
Front Immunol, 2022 ↗“I recently stopped taking Curcumin because of its affect on DHT and I was looking for an alternative measure to deal with inflammation as I feel it really helped with anxiety/depression.”
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“It has really improved the quality of my life, more than anything else I have taken.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate