Cagrilintide vs Retatrutide for appetite
Short answer: For appetite, more users report improvement with Cagrilintide — 100% of 8 reports, versus 73% of 86 for Retatrutide.
Cagrilintide has 9 meta-analyses and 15 randomized trials on PubMed; Retatrutide has 22 and 6.
Based on 32 reports about Cagrilintide and 460 about Retatrutide. Not medical advice.
| Cagrilintide Peptide | Retatrutide Peptide | |
|---|---|---|
| Users say it helped | 82%helped11 reports · few reports | 76%helped327 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 9 / 15 | 22 / 6 |
| Mainly used for | ||
| Weight loss % reporting improvement | 100% (7) | 92% (228) |
| Appetite % reporting improvement | 100% (8) | 73% (86) |
| Energy % reporting improvement | — | 69% (75) |
| Mood % reporting improvement | — | 66% (32) |
| Performance % reporting improvement | — | 82% (33) |
| Common side effects | fatigue, appetite loss, depressive episode | nausea, fatigue, stomach issues, insomnia |
| Typical dose reported | Not listed | Not listed |
GLP-1RAs are efficacious in treating adults with type 2 diabetes. Compared with the placebo, tirzepatide was the most effective GLP-1RA drug for glycaemic control by reducing haemoglobin A1c and fasting plasma glucose concentrations. GLP-1RAs also significantly improved weight management for type 2 diabetes, with CagriSema performing the best for weight loss. The results prompt safety concerns for GLP-1RAs, especially with high dose administration, regarding gastrointestinal adverse events.
BMJ, 2024 ↗“Cagri was a game changer for me. I added 1mg and thats been more than enough.”
This systematic review identifies the state and mechanism of action of emerging pharmacotherapies undergoing or having completed phase 2 and phase 3 clinical trials. The information provided herein furthers the understanding of obesity management, implying direct clinical implications and stimulating research initiatives.
Pharmacol Rev, 2025 ↗“Drastically reduced appetite: At 5mg, I experienced near-total suppression of hunger and cravings. Steady, effortless fat loss: I didn't have to track macros obsessively or do extreme cardio.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate