Adrafinil vs Lisdexamfetamine for focus
Short answer: For focus, users rate them about the same: 83% report improvement with Adrafinil (100 reports) and 87% with Lisdexamfetamine (200 reports).
Adrafinil has 0 meta-analyses and 0 randomized trials on PubMed; Lisdexamfetamine has 58 and 112.
Based on 399 reports about Adrafinil and 439 about Lisdexamfetamine. Not medical advice.
| Adrafinil Medication | Lisdexamfetamine Medication | |
|---|---|---|
| Users say it helped | 49%helped172 reports · high confidence | 41%helped281 reports · high confidence |
| Verdict | Mixed | Mixed |
| Research | DResearch: None | AResearch: Strong |
| Meta-analyses / RCTs | 0 / 0 | 58 / 112 |
| Mainly used for | ||
| Focus % reporting improvement | 83% (100) | 87% (200) |
| Energy % reporting improvement | 87% (93) | 61% (62) |
| Mood % reporting improvement | 79% (14) | 50% (82) |
| Anxiety % reporting improvement | 57% (7) | 39% (36) |
| Sleep % reporting improvement | 0% (6) | 12% (17) |
| Common side effects | liver stress, insomnia, liver damage, anxiety | anxiety, insomnia, fatigue, irritability |
| Typical dose reported | Not listed | Not listed |
“I take 300mg Adrafinil as soon as I get up, and usually in 90 minutes I can feel its effects. I don't get any high, no peak, no plateau and no crash.”
Our findings represent the most comprehensive available evidence base to inform patients, families, clinicians, guideline developers, and policymakers on the choice of ADHD medications across age groups. Taking into account both efficacy and safety, evidence from this meta-analysis supports methylphenidate in children and adolescents, and amphetamines in adults, as preferred first-choice medications for the short-term treatment of ADHD. New research should be funded urgently to assess long-term effects of these drugs.
Lancet Psychiatry, 2018 ↗“It's been a game changer for my focus and energy levels, really brought me back to life.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate