Adrafinil vs Amphetamine for focus
Short answer: For focus, users rate them about the same: 83% report improvement with Adrafinil (100 reports) and 85% with Amphetamine (428 reports).
Adrafinil has 0 meta-analyses and 0 randomized trials on PubMed; Amphetamine has 258 and 521.
Based on 399 reports about Adrafinil and 878 about Amphetamine. Not medical advice.
| Adrafinil Medication | Amphetamine Medication | |
|---|---|---|
| Users say it helped | 49%helped172 reports · high confidence | 35%helped606 reports · high confidence |
| Verdict | Mixed | Mixed |
| Research | DResearch: None | AResearch: Strong |
| Meta-analyses / RCTs | 0 / 0 | 258 / 521 |
| Mainly used for | ||
| Focus % reporting improvement | 83% (100) | 85% (428) |
| Energy % reporting improvement | 87% (93) | 75% (146) |
| Mood % reporting improvement | 79% (14) | 48% (132) |
| Anxiety % reporting improvement | 57% (7) | 38% (56) |
| Sleep % reporting improvement | 0% (6) | 9% (35) |
| Common side effects | liver stress, insomnia, liver damage, anxiety | tolerance, anxiety, insomnia, jitteriness |
| Typical dose reported | Not listed | Not listed |
“I take 300mg Adrafinil as soon as I get up, and usually in 90 minutes I can feel its effects. I don't get any high, no peak, no plateau and no crash.”
Overall, despite a class effect of improving clinical response relative to placebo, there were few differences among the individual ADHD pharmacotherapies, and most studies were at risk of at least one important source of bias. Furthermore, the certainty of the evidence was very low to low for all outcomes, and there was limited reporting of long-term adverse events. As such, the choice between ADHD pharmacotherapies may depend on individual patient considerations, and future studies should assess the long-term effects of individual pharmacotherapies on patient-important outcomes, including qu
PLoS One, 2020 ↗“Unfortunately the only thing that's ever works for me was using adderall. I didn't feel hungry until 3 pm and it was perfect.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate