PlainPill

What people actually say

175 first-hand quotes, shortened but never edited — each links to the original discussion.

AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
ExerciseMostly positive
“exercise is very potent and shown time and time again to rival antidepressants”
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ExerciseMostly positive
“Amazed no one mentioned exercise yet. This is HUGE for energy, focus, productivity”
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ExerciseMostly positive
“Try exercising more during the day. I've noticed that is the biggest contributor for deep sleep.”
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ExerciseMostly positive
“Exercise (by far the best thing)”
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ExerciseMostly positive
“Exercise!!! Get on the elliptical or lift some weights at least 4-5 days a week and see how you feel.”
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GlycineMostly positive
“Glycine (for when I'm out of bone broth)”
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GlycineMostly positive
“Fermented foods, fish oil and glycine can help with it.”
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GlycineMostly positive
“Glycine helped the most, a couple of grams a day.”
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GlycineMostly positive
“3. Glycine”
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GlycineMostly positive
“I've started it recently and has done a lot for my chronic fatigue. 3 g before bed does the trick. Massively helped my sleep quality”
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COQ10Mostly positive
“Try ubiquinol which is the reduced form of COQ10 AKA ubiquinone. Ubiquinol is more bioavailable.”
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COQ10Mostly positive
“Q10”
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COQ10Mostly positive
“Just ordered some CoQ10 w/ PQQ to try.”
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COQ10Mostly positive
“CoQ10 combo: ubiquinol 400 mg, PQQ 20 mg, ALA 50 mg, turmeric 50 mg”
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COQ10Mostly positive
“If you are taking metformin Co-Q10 is a must IMO but it has to be a strong dose in the oxidized form.”
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“1000Curcumin”
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“Curcumin”
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“I'd really like to create a patch of powerful senolytics to take while I sleep.”
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“The curcumin is for BPH (benign prostatic hyperplasia) and prostatitis both of which I have”
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“bacopa 500mg (45% baccosides), twice daily with 665mg curcumin.”
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NMNMixed
“It seems like NAD gets you back to youthful levels of health, but isn’t going to supercharge anyone who is still there.”
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NMNMixed
“Podcast Notes/Ful Summary - David Sinclair, Ph.D. on NMN, Resveratrol, and Longevity”
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NMNMixed
“NMN and resveratrol”
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NMNMixed
“NAD+ you're better off buying NMN and TMG oral supps. NMN will convert to NAD+ and TMG will replace the methyl groups”
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NMNMixed
“NMN - 500 mg”
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Intermittent FastingMostly positive
“8. Intermittent fasting”
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Intermittent FastingMostly positive
“I fast for at least 16 hours, most days it ends up being around 20.”
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Intermittent FastingMostly positive
“I would suggest trying Intermittent fasting. I have much better focus and clarity.”
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Intermittent FastingMostly positive
“To avoid any loose skin, my working strategy has been: intermittent fasting religiously”
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Intermittent FastingMostly positive
“I also did intermittent fasting for the first 4 months and lost my first 50 lbs that way.”
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CoffeeMixed
“I have heard the coffee is very good for reducing the risk of liver scar tissue”
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CoffeeMixed
“I micro-dose coffee, vitamin d, and lemon juice every morning”
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CoffeeMixed
“Quitting coffee did not improve my productivity, but it did improve my sleep quality and digestion a lot.”
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CoffeeMixed
“Aniracetam+vyvanse+coffee ? It is not a little too much?”
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CoffeeMixed
“Caffine will punch holes in my slow wave sleep, but racetams and mct will not... coffee is overrated”
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“Take Quercetin instead of antihistamines, its a natural one”
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“I'd really like to create a patch of powerful senolytics to take while I sleep.”
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“What's your opinion on other potentially anti-aging therapies like NMN & NR, NAD+ therapies, rapamycin, Dasatanib, resveratrol, and quercetin?”
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“Quercetin (500-1000mg) is another popular choice but it can cause insomnia... people have reported some short term memory problems”
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“Quercetin is sometimes brought up as an alternative, but it has the same transformation problems”
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