PlainPill
SupplementMood

Vitamin K

People mainly take Vitamin K for mood. Based on 63 first-hand reports and 1,080 meta-analyses & systematic reviews in the medical literature. Ranked #386 of 1,974 overall.

Compare with…Alternatives for mood
31
User score
Mostly positive
21% positive3% mixed2% negative75% unclear

Of reports that state an outcome, 81% are positive.

Clinical research
AStrong research base
1,080
meta-analyses
714
RCTs
21,762
papers

What Vitamin K does, according to users

Of the people who reported each effect, the share who said it got better.

Mood100% of 2Memory100% of 1Anxiety100% of 1Energy100% of 1Libido100% of 1Skin & hair100% of 1Longevity100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Chest · 2023 · Meta-analysis / systematic review
Perioperative Management of Vitamin K Antagonists and Direct Oral Anticoagulants: A Systematic Review and Meta-analysis

Conclusion: The certainty in the evidence supporting the perioperative management of anticoagulants remains limited. No high-quality evidence exists to support the practice of heparin bridging during the interruption of VKA or DOAC therapy for an elective surgery or procedure, or for the practice of interrupting VKA therapy for minor procedures, including cardiac device implantation, or continuation of a DOAC vs short-term interruption of a DOAC in the perioperative period.

PubMed 36462533 ↗
Front Public Health · 2022 · Meta-analysis / systematic review
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials

Conclusion: The results of this meta-analysis seem to indicate that VK2 supplementation has a positive effect on the maintenance and improvement of BMD LS in postmenopausal women, and it can also reduce the fracture incidence, serum uc-OC levels and the ratio of uc-OC to cOC. In conclusion, VK2 can indirectly promote bone mineralization and increase bone strength.

PubMed 36033779 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

120 mgas reported
45 mgdaily
100 mcgwith breakfast
dailyas reported
1000as reported
1-2x weeklyas reported

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Already doing omega3 and vitamins k and d.”
Source discussion ↗
“Nature Made Vitamin D - 3000 IU - and Vitamin K1/K2 - 120 mg, for bone density and strength”
Source discussion ↗
“I've been taking 45mg (yes, milligrams, something like 55000% of daily dosage) of vitamin K every day for the past two years as it works for my cancer.”
Source discussion ↗
“Vitamin K 1000 Phylloquinone (Arterial Damage, bone density, insulin sensitivity)”
Source discussion ↗
“Vitamin D, K, magnesium.”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate