What are the side effects of Syrian Rue?

Users most often report nausea, stomach issues, serotonin syndrome, fear, immobility. Side effects came up 7 times across 6 reports.

User reports can't establish safety. PubMed lists 1 meta-analyses and 0 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Syrian Rue side effects

Across 6 first-hand reports, people mentioned a side effect 7 times (about 117 per 100 reports). The most common: nausea, stomach issues, serotonin syndrome. User reports show what people notice — they can't tell you whether Syrian Rue is safe for you.

Reported side effects

nausea2

stomach issues1

serotonin syndrome1

fear1

immobility1

passed out1

In their own words

“I also got serotonin syndrome when I took rosea rhodiola extract and then Syrian rue an hour later.”

Didn't helpRead the discussion ↗

“I find it literally impossible to be sad on it. It should only be taken alone because it's quite potent”

HelpedRead the discussion ↗

Is Syrian Rue safe? What the research covers

BResearch: Moderate1 meta-analyses · 0 randomized trials on PubMed

J Psychoactive Drugs · 2017

Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies

Conclusion: These effects seem be mediated by monoamine oxidase or acetylcholinesterase inhibition, upregulation of glutamate transporters, decreases in reactive oxygen species, increases in neurotrophic factors, and anti-inflammatory effects. The neuroprotective and cognitive-enhancing effects of harmine should be further investigated in both preclinical and human studies.