PlainPill
SubstanceMood

Syrian Rue

People mainly take Syrian Rue for mood. Based on 6 first-hand reports and 1 meta-analyses & systematic reviews in the medical literature. Ranked #1768 of 4,149 overall.

Compare with…Alternatives for mood
19
User score
Mostly positive
33% positive0% mixed17% negative50% unclear

Of reports that state an outcome, 66% are positive.

Clinical research
BModerate research base
1
meta-analyses
0
RCTs
13
papers

What Syrian Rue does, according to users

Of the people who reported each effect, the share who said it got better.

Mood100% of 2
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

J Psychoactive Drugs · 2017 · Meta-analysis / systematic review
Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies

Conclusion: These effects seem be mediated by monoamine oxidase or acetylcholinesterase inhibition, upregulation of glutamate transporters, decreases in reactive oxygen species, increases in neurotrophic factors, and anti-inflammatory effects. The neuroprotective and cognitive-enhancing effects of harmine should be further investigated in both preclinical and human studies.

PubMed 27918874 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

0.1 mgevery morning
single doseas reported

Reported side effects

How often each side effect came up across all reports.

nausea ×2stomach issues ×1serotonin syndrome ×1fear ×1immobility ×1passed out ×1

What users say

First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.

“Syrian Rue extract is working wonders for me. 0.1mg Harmine/Harmaline HCL every morning.”
HelpedRead the discussion ↗
“I also got serotonin syndrome when I took rosea rhodiola extract and then Syrian rue an hour later.”
Didn't helpRead the discussion ↗
“I find it literally impossible to be sad on it. It should only be taken alone because it's quite potent”
HelpedRead the discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate