Conclusion: We found evidence for levodopa positive interaction with coffee, fiber and vitamin C, as well as for the potential beneficial impact of low-fat and protein redistribution diet. Contrastingly, high-protein diet and ferrous sulfate supplements can negatively affect levodopa pharmacokinetics and effectiveness. For other drugs, the data of food impact are scarce. Based on the available limited evidence, all dopamine agonists (bromocriptine, cabergoline, ropinirole), tolcapone, rasagiline, selegiline in tablets, safinamide, amantadine and pimavanserin can be taken with or without a meal. Opicapone
Selegiline side effects
Across 157 first-hand reports, people mentioned a side effect 15 times (about 10 per 100 reports). The most common: anxiety, irritability, sleep disruption. User reports show what people notice — they can't tell you whether Selegiline is safe for you.
Reported side effects
anxiety3
irritability3
sleep disruption2
aggression2
insomnia2
funky feeling1
sleep deprivation1
cardiovascular damage1
What got worse for some people
In their own words
“At first it was fantastic. Motivation out of the blue high energy clear thinking. After a few weeks on selegiline I started to get very agitated, everything bothered me.”
“Selegiline makes me noticeably more motivated. It makes me sleep even more, which sucks.”
“I've been taking it consistently for over 2 years to lower prolactin. 1.25 mg sublingual, 5x/week... Very easily aroused and stronger erections. Reduced refractory period... I sleep like absolute shit.”
“I personally like it. Gives me a lot of drive and energy. Too much can make you antsy but if you titrate to the right amount it can work wonders. I take a sublingual dropper with 1mg / day.”
“Selegiline at high doses (it worked wonders for me at 30mg/day). 3-4 days of that and i was sleeping better and waking up at 6am ready to start the day.”
“I have played with taking selgin, which inhibits the breakdown of dopamine, therefore greatly increasing dopamine across the board, and it did literally nothing for me.”
Is Selegiline safe? What the research covers
AResearch: Strong64 meta-analyses · 153 randomized trials on PubMed
Curr Neuropharmacol · 2022
How to Optimize the Effectiveness and Safety of Parkinson's Disease Therapy? - A Systematic Review of Drugs Interactions with Food and Dietary SupplementsNephrol Dial Transplant · 2012
Antidepressants for depression in stage 3-5 chronic kidney disease: a systematic review of pharmacokinetics, efficacy and safety with recommendations by European Renal Best Practice (ERBP)