What side effects do people report with Selegiline?

Most often: anxiety, irritability, sleep disruption, aggression, insomnia.

What else do people take for mood?

Probiotics (100% of 54), Tianeptine (95% of 148), Ketamine (97% of 62), Bromantane (95% of 74), Saffron (92% of 165).

Does Selegiline help with mood?

Q: Does Selegiline help with mood?

Yes, for most people. 86% of 28 people who reported on Selegiline for mood say it improved; 0% noticed no change and 14% say it got worse.

Yes, for most people. 86% of 28 people who reported on Selegiline for mood say it improved. 0% noticed no change and 14% say it got worse. That is about the typical result for mood (84% across 108 options).

Mood: what users report

86%better28 reports · medium confidence

24 better0 no change4 worse

Ranked #58 of 108 for mood.

What people say about Selegiline and mood

“At first it was fantastic. Motivation out of the blue high energy clear thinking. After a few weeks on selegiline I started to get very agitated, everything bothered me.”

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“Selegiline makes me noticeably more motivated. It makes me sleep even more, which sucks.”

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“a low dose of selegiline/deprenyl has helped me with motivation. ... I only take 1.25mg-2.5mg a day and have the positive effects.”

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“Motivation has been my major focus in searching for nootropics. Racetams have been useless in this regard for me, but...The one drug I've found to be incredibly useful is selegiline.”

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What the research says

AResearch: Strong64 meta-analyses · 153 trials on PubMed

BMJ Ment Health · 2025

Effectiveness of pharmacological and non-pharmacological interventions for treatment-resistant depression in older patients: a systematic review and meta-analysis

Conclusion: We identified weak evidence that ketamine therapy and aripiprazole augmentation, and very weak evidence that TMS, PGP and cognitive remediation increased remission. Lack of evidence regarding routinely prescribed antidepressants and psychosocial treatments is problematic, requiring clinicians to extend evidence from younger populations.

Nephrol Dial Transplant · 2012

Antidepressants for depression in stage 3-5 chronic kidney disease: a systematic review of pharmacokinetics, efficacy and safety with recommendations by European Renal Best Practice (ERBP)

Side effects people mention

anxiety 3irritability 3sleep disruption 2aggression 2insomnia 2

What else is Selegiline used for?

Focus 95%of 21 Energy 95%of 20 Anxiety 60%of 10 Libido 100%of 6

Information only — not medical advice. How we count