People mainly take S-23 for performance, recovery, weight loss. Based on 17 first-hand reports and 6 meta-analyses & systematic reviews in the medical literature. Ranked #488 of 1,974 overall.
Of reports that state an outcome, 71% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Findings suggest smaller decreases in ASD diagnoses compared to earlier reviews. Future research is needed as concerns remain for impaired individuals without a diagnosis.
PubMed 30852784 ↗Conclusion: According to the data retrieved from patients who underwent MBS compared to nonoperated patients suffering from obesity, the overall risk for malignancy was lower in the MBS group. Additional information collected in this study revealed the behavior of specific types of cancer in response to induced weight loss by operative means. The benefit of surgery in patients suffering from obesity is not restricted to the improvement of obesity morbidity alone.
PubMed 39581814 ↗Conclusion: Regarding unipolar affective disorder this study confirms what we have shown for bipolar disorders in earlier studies: schizoaffective disorder falls between schizophrenia and affective disorders, and there are relevant quantitative differences in key illness characteristics, which supports the validity of the schizoaffective disorder concept. Contrary to our expectations heterogeneity is not larger in SAD than in UD and not substantially higher than in S. Lower reliability of the diagnosis of SAD therefore cannot be ascribed to higher variability of illness characteristics in SAD.
PubMed 26599364 ↗Conclusion: Trimetazidine efficacy was comparable to that of other non-heart-rate-lowering antianginal treatments in patients with stable angina pectoris.
PubMed 22122948 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“You will indeed have complete shutdown on the S-23. This shit is for sure legit.”
“S-23 is a selective androgen receptor modulator”
“All tests show 98%+ purity. It was a very simple process with this supplier”
“On s23 I get leaner fast and my nuts shrink just as fast lol.”
“It personally was my favorite cycle. The strength and size gains were better than RAD.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate