People mainly take Pyridoxal 5-Phosphate for energy, pain & inflammation. Based on 11 first-hand reports and 14 meta-analyses & systematic reviews in the medical literature. Ranked #1416 of 4,149 overall.
Of reports that state an outcome, 75% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP.
PubMed 19744961 ↗Conclusion: Lesion characterization was significantly improved in cirrhotic patients after administration of Mangafodipir trisodium ( p=0.002) but not in non-cirrhotic patients ( p=0.13). Mangafodipir trisodium is a safe and well-tolerated useful contrast agent in patients with cirrhosis.
PubMed 12835986 ↗Conclusion: The vast majority of patients with acute paracetamol overdose enjoy excellent outcomes with acetylcysteine alone. Although cimetidine and fomepizole inhibit CYP 2E1 in animals, there is insufficient evidence to recommend their use either as a primary treatment or adjunct therapy in paracetamol poisoning. Calmangafodipir remains investigational.
PubMed 32762579 ↗Conclusion: Serum PLP levels and methionine intake might be inversely associated with breast cancer risk, especially among postmenopausal women, which need to be confirmed.
PubMed 23907430 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.
“I've been getting a lot of energy with ~2000mg ALCAR and (IIRC) 300mg ALA, alpha-GPC, 50 mg p5p, and a curcumin/piperine cap”
“I was taking a little extra B6 (P5P)... After a month my feet started tingling really badly and going numb”
“Taking P5P instead of unmethylated B6 was game changer for me.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate