People mainly take Oxaloacetate for mood, longevity. Based on 4 first-hand reports and 4 meta-analyses & systematic reviews in the medical literature. Ranked #2574 of 4,149 overall.
Of reports that state an outcome, 100% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Conclusions: Though some DSs showed potential in reducing fatigue in ME/CFS, methodological limitations and inconsistent results hinder definitive conclusions. Future research should improve diagnostic criteria and include more diverse populations.
PubMed 39940333 ↗Conclusion: These findings reveal MBG-D archaea as an important ubiquitous benthic sedimentary archaeal group with specific mixotrophic metabolisms, so we proposed the name Thermoprofundales as a new Order within the Class Thermoplasmata. Globally, Thermoprofundales and other benthic archaea might synergistically transform benthic organic matter, possibly playing a vital role in sedimentary carbon cycle.
PubMed 30514872 ↗Conclusion: Because of small numbers of patients studied and methodological limitations the combined results are not sufficiently accurate to provide a solid basis for non-treatment decisions.
PubMed 11685309 ↗Conclusion: These findings provide novel insights into the metabolic etiology of SS, highlighting both protective and harmful metabolites.
PubMed 41335288 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.
“I tend to think more along the lines of... Jiaogulan, Oxaloacetate, Nicotinamide Riboside...”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate