What are the side effects of Methylated B12?

Users most often report agitation, anxiety, insomnia, jitteriness, paranoia. Side effects came up 6 times across 12 reports.

Methylated B12 side effects

Q: Is Methylated B12 safe?

User reports can't establish safety. PubMed lists 21 meta-analyses and 0 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Across 12 first-hand reports, people mentioned a side effect 6 times (about 50 per 100 reports). The most common: agitation, anxiety, insomnia. User reports show what people notice — they can't tell you whether Methylated B12 is safe for you.

Reported side effects

agitation1

anxiety1

insomnia1

jitteriness1

paranoia1

apathy1

What got worse for some people

Anxiety75% worse · 25% better · of 4

In their own words

“I tried methylated b12 on it's own and that gave me anxiety, can't win.”

Didn't helpRead the discussion ↗

“extremely high doses of methylb12 and methylfolate. I've been in a constant state of fight or flight and anxiety for months”

Didn't helpRead the discussion ↗

“methylated B12 work well for me… they made me a little agitated and hypomanic at first but then settled into a groove”

MixedRead the discussion ↗

Is Methylated B12 safe? What the research covers

BResearch: Moderate21 meta-analyses · 0 randomized trials on PubMed

Cochrane Database Syst Rev · 2024

Vitamin B12 supplementation during pregnancy for maternal and child health outcomes

Conclusion: Oral vitamin B12 supplementation during pregnancy may reduce the risk of maternal vitamin B12 deficiency and may improve maternal vitamin B12 concentrations during pregnancy or postpartum compared to placebo or no vitamin B12 supplementation, but the evidence is very uncertain. The effects of vitamin B12 supplementation on other primary outcomes assessed in this review were not reported, or were not reported in a format for inclusion in quantitative analyses. Vitamin B12 supplementation during pregnancy may improve maternal and infant vitamin B12 status, but the potential impact on longer-term

Maturitas · 2020

Sexually dimorphic DNA-methylation in cardiometabolic health: A systematic review

Conclusion: Our findings suggest that DNAm might be a promising molecular strategy for understanding sex differences in the pathophysiology of cardiometabolic diseases and that future studies should investigate the effects of sex on epigenetic mechanisms in cardiometabolic risk. In addition, we emphasize the gap between the translational potential and the clinical utilization of cardiometabolic epigenetics.