Across 37 first-hand reports, people mentioned a side effect 20 times (about 54 per 100 reports). The most common: addiction, neurotoxicity, excitotoxicity. User reports show what people notice — they can't tell you whether Methamphetamine is safe for you.
“Desoxyn (pharma meth) is absolutely the most effective ADHD med I've used. Seriously. I've never had such calm clarity. But there's a huge stigma attached”
“well besides my benzo, amph abuse i also dabbled into dope..i feel like ive done quite some damage to my brain and i have trouble remembering things...25mg in the morning..it actually helps my productivity alot and I can quit it anytime. its just im not productive without it...”
“There were a few years where I was on methamphetamines as well.”
“I was taking meth for almost a year... Ever since then my dopamine and gaba centers have been wrecked”
“methamphet is mountains more neurotoxic than adderall. as far as i know, meth is possibly one of the most neurotoxic drugs i can think of”
Conclusion: Overall, NAC treatment appears to be safe and tolerable. Further well designed, larger controlled trials are needed for specific psychiatric and neurological disorders where the evidence is favorable.