People mainly take Isoliquiritigenin for anxiety, mood. Based on 8 first-hand reports and 4 meta-analyses & systematic reviews in the medical literature. Ranked #1163 of 1,974 overall.
Of reports that state an outcome, 32% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: In addition, very few studies investigated xanthine compounds and their activities were inconsistent. We suggest more studies investigate the ability of chalcones and modifying their structure to find out other compounds with higher efficacy.
PubMed 31571371 ↗Conclusion: Drug repurposing represents an intriguing approach for addressing the limitations of traditional cancer drug development while effectively targeting the fundamental hallmarks of cancer. By leveraging existing medications with established safety profiles, this strategy offers potential for more rapid translation to clinical applications and may enhance the therapeutic arsenal against various cancer types.
PubMed 41014361 ↗Conclusion: The convergence of ancient ethnomedical use and robust modern pharmacology positions G. glabra as a promising adjunctive therapeutic for RA. Future directions should focus on community-based clinical trials, sustainable cultivation, benefit-sharing with knowledge holders, and the development of standardised extracts.
PubMed 41177239 ↗Conclusion: This comprehensive analysis has provided a pharmacological foundation for developing ISL-based therapeutic interventions against inflammation-driven human pathologies.
PubMed 41863469 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“it tremendously improves anxiety and reduces mental fatigue”
“Isoliquiritigenin”
“In combination with the isoliquiritigenin, ErinaMAX made my mind almost eerily quiet”
“Seems like half of the reviews indicate acute mood enhancement and half feel absolutely nothing at all.”
“I took Isoliquiritgenin daily, and in theory it should’ve probably lost some efficacy. It may have become a little less noticeable, but I could still tell.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate