PlainPill

Glutamate

People mainly take Glutamate for anxiety, sleep. Based on 5 first-hand reports and 591 meta-analyses & systematic reviews in the medical literature. Ranked #3020 of 4,149 overall.

8
User score
Mostly negative
0% positive0% mixed40% negative60% unclear

Of reports that state an outcome, 0% are positive.

Clinical research
AStrong research base
591
meta-analyses
870
RCTs
128,593
papers

What Glutamate does, according to users

Of the people who reported each effect, the share who said it got better.

betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Adv Nutr · 2025 · Meta-analysis / systematic review
Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Conclusion: Addressing public health concerns may promote soy foods as high-quality plant protein sources with low environmental impact and cost, particularly benefiting postmenopausal women and aligning with sustainable dietary patterns and guidelines. This study was registered in PROSPERO as CRD42023439239.

PubMed 39433088 ↗
Nutrients · 2023 · Meta-analysis / systematic review
The Effect of Non-Nutritive Sweetened Beverages on Postprandial Glycemic and Endocrine Responses: A Systematic Review and Network Meta-Analysis

Conclusion: Conclusions: The available evidence suggests that NNS beverages sweetened with single or blends of NNS have no acute metabolic and endocrine effects, similar to water. These findings provide support for NNS beverages as an alternative replacement strategy for SSBs in the acute postprandial setting.

PubMed 36839408 ↗
JAMA Netw Open · 2022 · Meta-analysis / systematic review
Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk: A Systematic Review and Meta-analysis

Conclusion: This systematic review and meta-analysis found that using LNCSBs as an intended substitute for SSBs was associated with small improvements in body weight and cardiometabolic risk factors without evidence of harm and had a similar direction of benefit as water substitution. The evidence supports the use of LNCSBs as an alternative replacement strategy for SSBs over the moderate term in adults with overweight or obesity who are at risk for or have diabetes.

PubMed 35285920 ↗
Prostate Cancer Prostatic Dis · 2024 · Meta-analysis / systematic review
Comparison of (18)F-based PSMA radiotracers with [(68)Ga]Ga-PSMA-11 in PET/CT imaging of prostate cancer-a systematic review and meta-analysis

Conclusion: [18F]DCFPyL was observed to be similar to [68Ga]Ga-PSMA-11. [18F]PSMA-1007 was observed to be less preferrable to [68Ga]Ga-PSMA-11 due to its high benign bone uptakes. Overall, there was not enough evidence in differentiating the radiotracers based on their clinical impacts.

PubMed 38017295 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

2.5 gdaily
2.5 g1x/day
high doseas reported

Reported side effects

How often each side effect came up across all reports.

dry mouth ×1dry eyes ×1rapid heart ×1insomnia ×1

What users say

First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.

Other options for anxiety

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate