What are the side effects of DMAE?

Users most often report headache, bloodshot eyes, jaw tension, nasal irritation, backlash. Side effects came up 11 times across 134 reports.

User reports can't establish safety. PubMed lists 1 meta-analyses and 4 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

DMAE side effects

Across 134 first-hand reports, people mentioned a side effect 11 times (about 8 per 100 reports). The most common: headache, bloodshot eyes, jaw tension. User reports show what people notice — they can't tell you whether DMAE is safe for you.

Reported side effects

headache4

bloodshot eyes1

jaw tension1

nasal irritation1

backlash1

vivid dreams1

insomnia1

tardive dyskinesia1

In their own words

“I was taking a hefty dose (~1.5g DMAE/day)... depression came back abruptly after I started taking piracetam (dosed with DMAE)... I stopped the DMAE... and it went away nearly overnight.”

Didn't helpRead the discussion ↗

“I have been using DMAE for a few weeks and it works pretty well, especially nasally (although it burns like hell)”

HelpedRead the discussion ↗

“Not feeling any difference.. I find it really weird I don't feel any different than I normally do.. no concentration boost or anything.”

Didn't helpRead the discussion ↗

“I've taken DMAE by itself in the past, and I remember it gave me a clean, mild stimulation, without the side effects and crash of typical stimulants.”

MixedRead the discussion ↗

“Is centrophenoxine same DMAE? I tried it but It increased my blood pressure and give me some headache, but overall it was good nootropic.”

MixedRead the discussion ↗

“DMAE and Alcar works well together. I have them in my stack. I would recommend Centro instead of DMAE because it doesn't have the backlash of DMAE”

MixedRead the discussion ↗

Is DMAE safe? What the research covers

BResearch: Moderate1 meta-analyses · 4 randomized trials on PubMed

Nutr Hosp · 2022

Dietary omega-3 LCPUFA intake in the prevention of neovascular age-related macular degeneration: a systematic review and meta-analysis

Conclusion: When assessing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) intake and wAMD risk a total of the three above studies were included, which also produced similar results. Conclusions: the highest DHA consumption reduced the risk of disease by 39 % (effect size: 0.61, 95 % CI [0.50, 0.74], I2 = 14 %, p = 0.31); compared with the lowest EPA consumption, the highest EPA consumption reduced the risk of wAMD by 32 % (ES: 0.68, 95 % CI [0.57, 0.82], I2 = 39 %, p = 0.20).