The short answer. There isn't much data on Digestive Enzyme yet — 4 mentions, 1 with a clear outcome — so treat these numbers as anecdotal. It is well studied — 5 meta-analyses on PubMed.
From 4 mentions in total — the rest didn't say how it went and aren't counted.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: On the other hand, the COS decrease inflammatory mediators, suppress the activation of NF-κB, increase the phosphorylation of kinase, and stimulate the proliferation of lymphocytes. Overall, this review brings evidence from experimental data about protective effect of COS.
PubMed 31781615 ↗Conclusion: Patients with CP consume a disproportionately high volume of resources.
PubMed 24661411 ↗Conclusion: The key features of ADMPs that help them retain their leading position in the pharmaceutical market are as follows: (i) their unique composition usually represented by a complex of biologically active substances; (ii) a high degree of affinity of the active ingredient of an ADMP to the human body and (iii) proved safety and clinical efficiency. Variability in the quality of raw ingredients, epidemiological situation and other conditions pose additional challenges for the development of ADMPs and for the standardisation.
PubMed 31116966 ↗Conclusion: Additionally, alterations in hormone secretion, notably insulin levels and disturbed glucose homeostasis, highlight the complex effects of fluoride on the pancreatic endocrine system. These findings underscore fluoride-induced pancreatic toxicity and highlight the need for a comprehensive understanding and mitigation strategies to safeguard pancreatic health.
PubMed 39162920 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate